Human Dermal Lymphatic Microvascular Endothelial Cells: HDLMVEC 人皮膚淋巴微血管內皮細胞：HDLMVEC
產品型號： 100LK-05a
Human Dermal Lymphatic Microvascular Endothelial (HDLMVEC) are isolated from lymphatic capillaries of normal human dermis. The lymphatic system interacts closely with the blood vascular system in maintaining tissue homeostasis. It plays a vital role in the body by regulating the immune system, transporting interstitial fluid, proteins and fat to the blood circulatory system. Lymphangiogenesis is also implicated in the metastatic process. Although lymphatic microvascular endothelial cells have many properties in common with blood microvascular endothelial cells, they also have unique functions due to their structural features. Lymphatic capillaries have thin and discontinuous base membranes, and lymphatic endothelial cells, unlike their blood vessel counterparts, are not as tightly connected with each other, rendering the capillaries highly permeable.
HDLMVEC, together with Human Umbilical Vein Endothelial Cells, both from Cell Applications, Inc., have recently been used in a study demonstrating the key role of Prox1 and FOX C2 proteins in angiogenesis and lymphangiogenesis associated with oral squamous cell carcinoma progression.
Characterization: They express VEGFR3, and respond to activation by VEGF-C (see Figure on left).
DETAILS
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Tissue
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Normal healthy human lymphatic capillaries from dermis
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QC
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No bacteria, yeast, fungi, mycoplasma, virus
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Character
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Factor VIII-related Ag, CD31 (PECAM-1), DiI-Ac-LDL uptake
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Bioassay
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Attach, spread, proliferate in Growth Med (AFS-coated surface)
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Cryovial
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500,000 HDLMVEC (3rd psg) frozen in Basal Medium w/ 10% FB, 10% DMSO
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Kit
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Cryovial of HDLMVEC (100L-05a), Gr Med (111-500), Attchmnt Fctr Soln (123-100), Subcltr Rgnt Kit (090K)
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Proliferating
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Shipped in Tsfr Med, 4th psg (flasks or plates)
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Doublings
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At least 12
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Applications
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Laboratory research use only (RUO). Not for human, clinical, diagnostic or veterinary use.
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PRODUCTS
| PRODUCT | SIZE | CAT.# |
| Cryopreserved HDLMVEC, Adult: 5x10^5 Cells (Adult), Medium & Subculture Reagents (See Details tab for specifics) | 1 Kit | 100LK-05a |
| Cryopreserved HDLMVEC, Adult: Frozen HDLMVEC (5x10^5) | 1 Cryovial | 100L-05a |
RELATED PRODUCTS
| PRODUCT | SIZE | CAT.# |
| Microvascular Endothelial Cell Basal Medium: Basal medium (contains no growth supplement). Add GS before use. | 500 ml | 100-500 |
| Microvascular Endothelial Cell Growth Medium: All-in-one ready-to-use | 500 ml | 111-500 |
| Microvascular Endothelial Cell Growth Medium Kit: Basal medium & growth supplement sold together packaged separately | Yields 500 ml | 111K-500 |
| Microvascular Endothelial Cell Growth Supplement: Added to Basal Medium to create Growth Medium | 30 ml | 111-GS |
| Human Microvascular Endothelial Cell Growth Medium Kit, separate: Basal medium & growth supplement sold, together packaged separately. Supplements in individual vials. | Yields 500 ml | 111KS-500 |
EXTENDED FAMILY PRODUCTS
| PRODUCT | SIZE | CAT.# |
| Monoclonal CD31 Antibody: Monoclonal CD31 Antibody | 100 ul | CB13678 |
| Anti-CD31: Mouse CD31 Antibody | 100 ul | CC10038 |
| Anti-ICAM-1: Rabbit Intercellular Adhesion Molecule-1 Antibody | 100 ul | CG1238 |
| Polyclonal Vascular Endothelial Growth Factor-C Antibody: Polyclonal Vascular Endothelial Growth Factor-C Antibody | 100 ul | CB3778 |
| Polyclonal VEGF Receptor 1 Antibody: Polyclonal VEGF Receptor 1 Antibody | 100 ul | CB3839 |
| Attachment Factor Solution (AFS): AFS, contains Bovine Gelatin | 100 ml | 123-100 |
| Freezing Medium: For general cryopreservation of most primary cells. Contains FBS & DMSO. | 50 ml | 040-50 |
| Cyto-X Cell Counting Reagent: 500 tests | 1 Bottle | 028-01 |
| Cyto-X Cell Counting Reagent Sample: 100 tests | Sample | 028-S |
| Cytofect™ Endothelial Cell Transfection Kit: 25 x 24-Well Rxns | 1 Sample Kit | TF101KS |
| Cytofect™ Endothelial Cell Transfection Kit: 250 x 24-Well Rxns | 1 Kit | TF101K |
| HDLMVEC RNA: Total RNA prepared from Human Dermal Lymphatic Microvascular Endothelial Cells, adult | 10 ug | 100L-R10a |
| HDLMVEC RNA: Total RNA prepared from Human Dermal Lymphatic Microvascular Endothelial Cells, adult | 25 ug | 100L-R25a |
| Human Gamma-Interferon Inducible Protein 10 (IP-10 / CXCL10): Human gamma-Interferon Inducible Protein 10 | 25 ug | RP1127-25 |
| Human Gamma-Interferon Inducible Protein 10 (IP-10 / CXCL10): Human gamma-Interferon Inducible Protein 10 | 100 ug | RP1127-100 |
| Human Gamma-Interferon Inducible Protein 10 (IP-10 / CXCL10): Human gamma-Interferon Inducible Protein 10 | 1000 ug | RP1127-1000 |
| Subculture Reagent Kit: 100 ml each of HBSS, Trypsin/EDTA & Trypsin Neutralizing Solution | 1 Kit | 090K |
| Human Vascular Endothelial Growth Factor-121 (VEGF-121): Human Vascular Endothelial Growth Factor-121 | 10 ug | RP1116-10 |
| Human Vascular Endothelial Growth Factor-121 (VEGF-121): Human Vascular Endothelial Growth Factor-121 | 100 ug | RP1116-100 |
| Human Vascular Endothelial Growth Factor-121 (VEGF-121): Human Vascular Endothelial Growth Factor-121 | 1000 ug | RP1116-1000 |
| Human VEGF-121, Animal-Free: Human Vascular Endothelial Growth Factor-121, Animal-Free | 10 ug | RP1116AF-10 |
| Human VEGF-121, Animal-Free: Human Vascular Endothelial Growth Factor-121, Animal-Free | 100 ug | RP1116AF-100 |
| Human VEGF-121, Animal-Free: Human Vascular Endothelial Growth Factor-121, Animal-Free | 1000 ug | RP1116AF-1000 |
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